PhD Thesis Offer in Université Paris Descartes (2018-2019)

mercredi 9 mai 2018 par ggerbaud

Development and applications of EPR probes of oxidative stress.

The level of reactive oxygen species, such as superoxide anion and hydroxyl radical, is tightly regulated by antioxidant enzymes or small molecules in vivo. However, when the balance is lost, a situation of oxidative stress can occur in cells with accumulation of damages to proteins, lipids, and nucleic acids. These lesions can be analysed by ex vivo methods and oxidative stress is involved in a large number of pathological situations (inflammation, cancer, neurodegenerative diseases...). The non-invasive detection and mapping of oxidative stress in vivo would give valuable information on disease development and help develop diagnostic and therapeutic tools.
In recent years, we focused on developing new redox-sensitive probes derived from tetraethyl-substituted aminoxyl radicals (nitroxides) or hydroxylamines to monitor oxidative stress by differential measurements on pathological and control animals by electron paramagnetic resonance (EPR) spectroscopy. The previous PhD project allowed us to perform a structure-activity relationship study and to validate the hypothesis with the lead compound on cultured cells. This opens the way for the current PhD project focused on further probe optimization and in vivo applications.

Detailed offer :

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